| 货号 | AF3540-SP |
| 别名 | GFI-1; growth factor independence-1; growth factor independent 1 transcription repressor; growth factor independent 1; Growth factor independent protein 1; Pal-1; SCN2; Zinc finger protein 163; zinc finger protein Gfi-1; ZNF163; ZNF163FLJ94509 | 全称 | Growth Factor Independent 1 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunocytochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects human GFI-1 in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunocytochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2672 (Human); 14581 (Mouse); 24388 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1 | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human GFI-1 Pro2-Leu250 Accession # Q99684 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Human GFI-1 is a 55 kDa, 422 amino acid (aa) nuclear, zinc-finger transcriptional regulator. It contains an N-terminal SNAG domain, an Ala/Gly-rich region, and a C‑terminus with six C2H2-type zinc finger motifs. GFI-1 binds DNA in a sequence-specific manner. GFI-1 functions as a transcription repressor in lymphoid cells and is required for neutrophil maturation. It also regulates self-renewal and is essential for the functional integrity of hematopoietic stem cells. Over the region used for immunization, human GFI-1 shares less than 50% amino acid sequence homology with human GFI-1B. It also shares 79% and 89% aa sequence identity with mouse and canine GFI-1, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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