| 货号 | AF3316-SP |
| 别名 | dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1 (Drosophila); dishevelled-1; DSH homolog 1; Dsh; DVL; DVL1; DVL1L1; MGC54245; segment polarity protein dishevelled homolog DVL-1 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects human Dishevelled-1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) DVL‑2 and rhDVL‑3 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1855 (Human); 13542 (Mouse); 83721 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Dishevelled-1 Arg150-Leu215 Accession # O14640 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | DVL-1 (Dishevelled-1) is a cytoplasmic phosphoprotein that is one of the three human orthologs of the Drosophila dishevelled segment polarity protein. Human DVL-1 is expressed in multiple tissues where it participates in Wnt signal transduction. DVL-1 is a modular protein containing DIX, PDZ and DEP linker regions that connect Wnt/Frizzled engagement to proteins involved in the inactivation of beta -catenin destruction in the Wnt canonical pathway. Human DVL-1 shows 93% aa identity with mouse and rat DVL-1 over the sequence used for immunization. Three shorter isoforms have been described, but it is unclear whether these are actually expressed. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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