Human DSCAM-L1 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human DSCAM-L1 Affinity Purified Polyclonal Ab (25 UG)

货号： AF3315-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF3315-SP
别名	Down syndrome cell adhesion molecule like 1; Down syndrome cell adhesion molecule-like protein 1; Downs syndrome cell adhesion molecule like 1; DSCAM2; KIAA1132Down syndrome cell adhesion molecule 2
全称	Down Syndrome Cell Adhesion Molecule Like 1
反应种属	Human
应用	Western Blot(0.1 µg/mL) Flow Cytometry(2.5 µg/10⁶cells)
目标/特异性	Detects human DSCAM-L1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human DSCAM is observed.
使用方法	Western Blot: 0.1 µg/mL Flow Cytometry: 2.5 µg/10⁶cells
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	57453 (Human); 114873 (Mouse); 315615 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. DSCAM promotes axon fasciculation and growth in the developing optic pathway Authors: FM Bruce, S Brown, JN Smith, PG Fuerst, L Erskine Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. Species: Mouse Sample Type: Whole Cells Application: ICC
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human DSCAM-L1 Glu19-Lys1591 Accession # Q8TD84
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	DSCAM-L1 is a 250 kDa type I transmembrane Ig superfamily glycoprotein that is predominantly expressed in Purkinje cells and neurons of the cerebral cortex and olfactory bulb.DSCAM-L1 mediates cell adhesion by cation-independent homophilic interactions. It may function in the formation and maintenance of neural networks and play a role in neural disorders such as Gilles de la Tourette and Jacobsen syndromes. Human DSCAM-L1 contains ten Ig-like C2-type domains and six fibronectin type-III domains. An alternately spliced isoform is generated by deletion of 211 amino acids near the N-terminal. Within the extracellular domain, human DSCAM-L1 shares 98% amino acid sequence identity with mouse and rat DSCAM-L1.
运输条件	Blue Ice
存放说明	4℃
参考文献	Immunoglobulin Superfamily CAMs Netrins and Receptors Synaptic Adhesion Molecules

参考图片

Detection of DSCAM‑L1 in A172 Human Cell Line by Flow Cytometry. A172 human glioblastoma cell line was stained with Goat Anti-Human DSCAM‑L1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3315, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).