| 货号 | AF3129-SP |
| 别名 | amyloid beta (A4) precursor-like protein 1; amyloid precursor-like protein 1; amyloid-like protein 1; APLPAPLP-1 | 全称 | Amyloid-like Protein 1 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects human APLP‑1 in Western blots. In Western blots, approximately 15% cross-reactivity with recombinant mouse APLP-1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1803 (Human); 333 (Human); 502317 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human APLP-1 Gln34-Glu580 Accession # P51693 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | APLP-1 is a transmembrane metalloprotein that is expressed in centralneurons. Similar to APP and APLP-2, APLP-1 is susceptible to cleavageby various secretases, generating multiple fragments from theextracellular and intracellular domains. These include peptides similarto the amyloidogenic A beta peptides and a cytoplasmic fragment thatassociates with Fe65 family proteins and functions as a transcriptionalactivator. The extracellular domain contains heparin and collagenbinding regions and is 89% identical between human and mouse. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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