Human LINGO-1 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human LINGO-1 Affinity Purified Polyclonal Ab (25 UG)

货号： AF3086-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF3086-SP
别名	FLJ14594; LERN1; LERN1UNQ201; leucine rich repeat and Ig domain containing 1; leucine rich repeat neuronal 6A; Leucine-rich repeat and immunoglobilin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A; LRRN6A; LRRN6Aleucine-rich repeat neuronal 6A; MGC17422
全称	Leucine-rich Repeat And Ig Domain Containing Nogo Receptor-Interacting Protein 1
反应种属	Human
应用	Western Blot(0.1 µg/mL) Immunohistochemistry(1.7-15 µg/mL)
目标/特异性	Detects human LINGO-1 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human LINGO-2 is observed.
使用方法	Western Blot: 0.1 µg/mL Immunohistochemistry: 1.7-15 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	84894 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. Authors: Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H, Kolbe L, Hearing VJ J. Invest. Dermatol., 2010;130(6):1685-96. Species: Human Sample Type: Whole Tissue Application: IHC Paraffin-embedded Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. Authors: Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ J. Neurosci., 2008;28(11):2753-65. Species: Rat Sample Type: Cell Lysates Application: WB
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human LINGO-1 Thr40-Thr556 Accession # NP_116197
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	LINGO-1 (LRRN6A) is a 614 aa transmembrane protein of the leucine-rich repeat (LRR) family, ribonuclease inhibitor subfamily. The four known LINGO proteins contain LRR and IgCAM domains in the extracellular portion and share 44‑61% aa identity. LINGO-1 is restricted to the nervous system and is concentrated in the brain as a component of the NgR1/p75 and NgR1/Taj (TROY) signaling complexes. LINGO-1 negatively regulates neurite outgrowth and myelination. LINGO-1 is highly conserved, showing 99% aa identity between human, mouse and rat.
运输条件	Blue Ice
存放说明	4℃
参考文献	Glial Lineage Markers Neurotrophin/Trk Family Nogo Proteins and Receptors

参考图片

LINGO‑1 in Mouse Spinal Cord. LINGO‑1 was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Human LINGO‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3086) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to the dorsal horn. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.