| 货号 | AF2664-SP |
| 别名 | CD305 antigen; CD305; CD305leukocyte-associated Ig-like receptor 1; hLAIR1; LAIR-1; leukocyte-associated immunoglobulin-like receptor 1 | 全称 | Leukocyte-associated Ig-like Receptor 1 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Flow Cytometry(0.25 µg/106cells) |
| 目标/特异性 | Detects human LAIR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant human LAIR2 is observed and less than 2% cross-reactivity with recombinant mouse LAIR1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Flow Cytometry: 0.25 µg/106cells |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3903 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human LAIR1 isoform 1 Gln22-His163 Accession # Q6GTX8 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | LAIR-1 is an inhibitory receptor belonging to the Ig superfamily. It isa type I transmembrane protein with one extracellular Ig-like domainand two cytoplasmic ITIMs. Four LAIR-1 splice variants exist. LAIR1bhas a 17 aa deletion outside the Ig loop in the extracellular domain.It differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncationin the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, Bcells, monocytes, dendritic cells and most thymocytes. Theextracellular domain of human LAIR1 shares 40% aa identity with that ofthe mouse protein. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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