| 货号 | AF2635-SP |
| 别名 | botv; DKFZp686C2342; EC 2.4.1.223; exostoses (multiple)-like 3; exostosin-like 3; EXTL1L; EXTL3; EXTR1BOTV; EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; KIAA0519; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3; reg receptor; REG; REGR; RPR |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Exostosin-like 3/EXTL3 Lumenal Domain in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2137 (Human) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Exostosin-like 3/EXTL3 Lumenal Domain Thr52-Ile919 Accession # O43909 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Exostosin-like 3 (EXTL3) is an ER-resident type II transmembrane protein belonging to the EXT family of tumor suppressor genes. EXT family members are glycosyl transferases that are involved in the synthesis of the glycosaminoglycan chains of heparan sulfate proteoglycans. EXTL3 was also reported to be a receptor for the REG protein, a pancreatic beta-cell regeneration factor. The lumenal domains of human, mouse and rat share 97% amino acid sequence identity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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