| 货号 | AF2627-SP |
| 别名 | PCOLCE; PCPE; PCPE-1; PCPE1Type I procollagen COOH-terminal proteinase enhancer; procollagen C-endopeptidase enhancer 1; procollagen C-endopeptidase enhancer; Procollagen COOH-terminal proteinase enhancer 1; Procollagen C-proteinase enhancer 1; procollagen, type 1, COOH-terminal proteinase enhancer; Type 1 procollagen C-proteinase enhancer protein | 全称 | Procollagen C-Proteinase Enhancer-1 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects human PCPE-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant mouse PCPE-1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5118 (Human); 18542 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human PCPE-1 Met1-Asp449 Accession # Q15113 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | PCPE-1 is a 55 kDa extracellular protein that lacks intrinsic enzymaticactivity. It functions as a substrate-specific adaptor protein thatstimulates C-terminal processing of the fibrillar procollagens I, IIand III by PCP (also known as BMP-1/tolloid metalloproteinases). PCPEis naturally processed into N-terminal fragments of 34 and 36 kDas,both of which also enhance PCP. A 16.5 kDa protein corresponding to aC-terminal fragment of PCPE has been described and shown to havemetalloproteinase inhibitor activity. Human PCPE-1 shares approximately81% amino acid sequence homology with mouse and rat PCPE-1. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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