| 货号 | AF1548-SP |
| 别名 | TAJ; TAJ-alpha; TAJToxicity and JNK inducer; TNFRSF19; TRADE; TROYtumor necrosis factor receptor superfamily member 19; tumor necrosis factor receptor superfamily, member 19 | 全称 | Tumor Necrosis Factor Receptor Superfamily, Member 19 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human TROY/TNFRSF19 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) TROY is observed and less than 1% cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFas, rhGITR, rhHVEM, rhNGF R, rhOPG, rhRANK, rhTNF RI, and rhTNF RII is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 55504 (Human); 29820 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TROY/TNFRSF19 Glu30-Leu170 Accession # AAF71828 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | TROY, also known as TAJ (Toxicity and JNK inducer), and TRADE, is a type I tramsmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF19. Two alternatively spliced transcript variants for human TROY, encoding a 423 amino acid (aa) residues isoforms 1 precursor and a 417 aa isoform 2 precursor have been cloned. The two isoforms differ in their cytoplasmic C-terminal residues. In mouse, a soluble TROY isoform and a transmembrane isoform with a short cytoplasmic tail have also been described. Human TROY isoform 1 cDNA encodes a precursor protein with a putative 23 aa signal peptide, a 147 aa extracellular domain containing two TNF receptor cysteine-rich domains, a 23 aa transmembrane domain and a 230 aa cytoplasmic region containing no death domain. The extracellular domain of human TROY shares 92% aa sequence identity with that of the mouse TROY. In their cytoplasmic domains, the two proteins also share 57% sequence homology. Among TNFRSF members, the extracellular region of TROY is most closely related to EDAR, exhibiting 33% homology. TROY expression has been found in many different embryonic and adult tissues, and is particularly strong in embryonic brain and skin. TROY has been shown to interact with TRAF family members, and to activate the JNK signaling pathway. Although TROY lacks a death domain, it can induce apoptosis by a caspase-independent mechanism. It has been suggested that TROY has pleiotropic functions during embryonic development as well as in adults, particularly in the development of skin and hair follicles. The ligand for TROY has not been identified (1‑3). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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