| 货号 | 3661L |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody detects endogenous levels of ACC only when phosphorylated at serine 79. The antibody recognizes both ACCalpha and ACCbeta. |
| 使用方法 | WB(1:1000) IP (1:100) IHC-P (1:800) |
| 供应商 | CST |
| 背景 | Acetyl-CoA Carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart (1). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (2). ACC is a potential target of anti-obesity drugs (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 280 |
Western blot analysis of extracts from HEK293 cells, untreated or oligomycin-treated, using Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody. Wetern blot检测 HEK293 细胞提取物，细胞未处理或用寡霉素处理，所用抗体为Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, showing cytoplasmic localization, using Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody. 免疫组织化学检测石蜡包埋的人乳腺癌组织，显示胞质定位。所用抗体为Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody。 | |
Immunohistochemical analysis of paraffin-embedded NIH/3T3 cells, untreated (left) or serum-starved (right), using Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody. 免疫组织化学检测石蜡包埋的 NIH/3T3 细胞，细胞未处理（左）或血清饥饿处理（右）。所用抗体为Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody。 |
