PD-L1 FoxP3 Complex Kits
货号:
78701T 基本售价:
6000.0 元 规格:
-
产品信息
概述货号 | 78701T |
反应种属 | Human |
目标/特异性 | Each antibody in this panel recognizes endogenous levels of its specific target protein. |
性能供应商 | CST |
背景 | The field of cancer immunotherapy is focused on empowering the immune system to fight cancer. This approach has seen recent success in the clinic with targeting immune checkpoint control proteins, such as PD-1 (1,2). Despite this success, clinical biomarkers that predict response to therapeutic strategies involving PD-1 receptor blockade are still under investigation (3-5). While PD-L1 expression has been linked with an increased likelihood of response to anti-PD-1 therapy, research studies have shown that additional factors, such as tumor-immune infiltration and the ratio of effector to regulatory T cells within the tumor, could play a significant role in predicting treatment outcome (6-9). |
参考文献 | Topalian, S.L. et al. (2012) N Engl J Med 366, 2443-54. Piccinini, M. et al. (2014) Comput Methods Biomech Biomed Engin 17, 1403-17. Chakravarti, N. and Prieto, V.G. (2015) Transl Lung Cancer Res 4, 743-51. Sholl, L.M. et al. (2016) Arch Pathol Lab Med , . Carbognin, L. et al. (2015) PLoS One 10, e0130142. Tokito, T. et al. (2016) Eur J Cancer 55, 7-14. Tumeh, P.C. et al. (2014) Nature 515, 568-71. Feng, Z. et al. (2015) J Immunother Cancer 3, 47. Baine, M.K. et al. (2015) Oncotarget 6, 24990-5002. Dong, H. et al. (2002) Nat Med 8, 793-800. Thompson, R.H. et al. (2006) Cancer Res 66, 3381-5. Pardoll, D.M. (2012) Nat Rev Cancer 12, 252-64. Ochs, H.D. et al. (2007) Immunol Res 38, 112-21. Bennett, C.L. et al. (2001) Nat Genet 27, 20-1. Kasprowicz, D.J. et al. (2003) J Immunol 171, 1216-23. Zuo, T. et al. (2007) Cell 129, 1275-86. Zuo, T. et al. (2007) J Clin Invest 117, 3765-73. Wang, L. et al. (2009) Cancer Cell 16, 336-46. Zamoyska, R. (1994) Immunity 1, 243-6.
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参考图片Fluorescent multiplex immunohistochemical analysis of paraffin-embedded human tonsil using PD-L1 (E1L3N®) XP® Rabbit mAb (green), FoxP3 (D2W8E™) Rabbit mAb (IHC Specific) (yellow), and CD8α (C8/144B) Mouse mAb (IHC Specific) (Red). Blue pseudocolor = DAPI #8961 (fluorescent DNA dye). Image acquisition was performed with a multispectral camera. |
Fluorescent multiplex immunohistochemical analysis of paraffin-embedded human breast cancer using PD-L1 (E1L3N®) XP® Rabbit mAb (green), FoxP3 (D2W8E™) Rabbit mAb (IHC Specific) (yellow), and CD8α (C8/144B) Mouse mAb (IHC Specific) (Red). Blue pseudocolor = DAPI #8961 (fluorescent DNA dye). Image acquisition was performed with a multispectral camera. |