Phospho-α-E-Catenin (Ser652) Antibody【科瑞奥博】

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Phospho-α-E-Catenin (Ser652) Antibody

货号： 13061S 基本售价： 3980.0 元规格： -

产品信息

概述
货号	13061S
反应种属	Human/Mouse/Rat/Monkey
来源宿主	Rabbit
应用	W
目标/特异性	Phospho-α-E-Catenin (Ser652) Antibody recognizes endogenous levels of α-E-catenin protein only when phosphorylated at Ser652.
使用方法	WB(1:1000)

性能
供应商	CST
灵敏度	Endogenous
背景	Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of the transmembrane proteins, cadherins, which bind cadherins on adjacent cells in a calcium-dependent manner. On the cytoplasmic side of adherens junctions, the classic model states that cadherins are linked to the cytoskeleton through β- and α-catenin. α-E-catenin is ubiquitously expressed, α-N-catenin is expressed in neuronal tissue, and α-T-catenin is primarily expressed in heart tissue. Research studies have demonstrated that loss of E-cadherin and α-E-catenin occurs during the progression of several human cancers, indicating that the breakdown of adherens junctions is important in cancer progression (reviewed in 1).
存放说明	-20C
计算分子量	100
参考文献	1 . Kobielak, A. and Fuchs, E. (2004) Nat Rev Mol Cell Biol 5, 614-25. 2 . Yamada, S. et al. (2005) Cell 123, 889-901. 3 . Drees, F. et al. (2005) Cell 123, 903-15. 4 . Hwang, S.G. et al. (2005) J Biol Chem 280, 12758-65. 5 . Ji, H. et al. (2009) Mol Cell 36, 547-59. 6 . Rigbolt, K.T. et al. (2011) Sci Signal 4, rs3. 7 . Brill, L.M. et al. (2009) Cell Stem Cell 5, 204-13. 8 . Chen, L. et al. (2010) J Proteome Res 9, 174-8.

参考图片

Western blot analysis of extracts from NCI-H3255 cells, untreated (-) or treated with λ phosphatase (+), using Phospho-α-E-Catenin (Ser652) Antibody (upper), α-E-Catenin (23B2) Rabbit mAb #3240 (middle) and β-Actin (D6A8) Rabbit mAb #8457 (lower).未处理(-)或λ phosphatase处理(+)的NCI-H3255细胞，使用Phospho-α-E-Catenin (Ser652) Antibody (上), α-E-Catenin (23B2) Rabbit mAb #3240 (中) 和 β-Actin (D6A8) Rabbit mAb #8457 (下)进行western blot分析。

Western blot analysis of extracts from various cell lines using Phospho-α-E-Catenin (Ser652) Antibody.使用Phospho-α-E-Catenin (Ser652) Antibody对多种细胞提取物进行western blot分析。