| 货号 | 9321S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Tyk2 (Tyr1054/1055) Antibody detects endogenous levels of Tyk2 only when phosphorylated at tyrosine1054/1055. The antibody does not cross-react with Tyk2 phosphorylated at other sites. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta (1-3). Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade (5). |
| 存放说明 | -20C |
| 计算分子量 | 134 |
| 参考文献 | 1 . Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327-34. 2 . Stahl, N. et al. (1994) Science 263, 92-5. 3 . Leonard, W.J. and OShea, J.J. (1998) Annu Rev Immunol 16, 293-322. 4 . Gauzzi, M.C. et al. (1996) J Biol Chem 271, 20494-500. 5 . Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507-11. |
Western blot analysis of extracts from HeLa cells, untreated or interferon-alpha treated for the indicated times, using Phospho-Tyk2 (Tyr1054/1055) Antibody (upper) or Tyk2 antibody (lower).Western免疫印迹。用Phospho-Tyk2 (Tyr1054/1055) Antibody (上图) or Tyk2 antibody (下图)抗体研究未经处理或经干扰素—alpha处理一定时间的HeLa 细胞的细胞提取液。 |
