Phospho-Talin (Ser425) Antibody
货号：
5426S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 5426S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Talin (Ser425) Antibody detects endogenous levels of talin protein only when phosphorylated at Ser425. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Focal adhesions connect the cytoskeleton with the extracellular matrix (ECM), a complex structure of secreted macromolecules that surrounds mammalian organs and tissues. Integrins clustered on the extracellular side of focal adhesions signal from the ECM to intracellular protein complexes, which in turn signal to the actin cytoskeleton to regulate the tension needed for cell motility. Internal signals also converge on focal adhesions to regulate integrin affinity and avidity. Signaling through focal adhesions regulates cell adhesion, migration, proliferation, apoptosis and gene expression, and impacts cellular processes such as development, wound healing, immune response, invasion, metastasis and angiogenesis (reviewed in 1-3). Talin is a large, multidomain focal adhesion protein that interacts with the intracellular domains of integrins and other focal adhesion proteins. Talin is involved in the formation of focal adhesions and in linking focal adhesions to the actin cytoskeleton (4). The interaction between talin and integrins increases the affinity between integrin and both insoluble and soluble ECM proteins (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 270 |
参考图片Western blot analysis of extracts from 293T cells, untreated or treated with λ and calf intestinal phosphatases using Phospho-Talin (Ser425) Antibody (upper) or Talin-1 (C45F1) Rabbit mAb #4021 (lower).未处理或经过λ和牛小肠碱性磷酸酶处理的293T细胞提取，使用 Phospho-Talin (Ser425)抗体（上）或Talin-1（C45F1）兔单抗#4021抗体进行western blot分析。 |
