Phospho-TAK1 (Thr184) Antibody
货号：
4537S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4537S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1 (1,2). In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1 (3,4). Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation (5). Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK) (2). |
| 存放说明 | -20C |
| 计算分子量 | 82 |
参考图片Western blot analysis of extracts from 293 IL-1R cells treated with IL-1beta (10 ng/ml) and Calyculin A (50 nM) for the indicated times, using Phospho-TAK1 (Thr184) Antibody.western blot方法检测细胞提取物： IL-1beta (10 ng/ml) 、Calyculin A (50 nM)按规定时间处理的293IL-1R细胞。使用的抗体是Phospho-TAK1 (Thr184) Antibody。 |
