Phospho-Syk (Tyr525/526) Antibody
货号：
2711S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 2711S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Syk (Tyr525/526) Antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr525/526 of human Syk (Tyr519/520 of mouse Syk). It does not cross-react with other tyrosine-phosphorylated members of the Syk/Zap-70 tyrosine kinase family. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells (1-3). Syk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors (4). It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation and phagocytosis (4). There is also evidence of a role for Syk in nonimmune cells, and Syk is a potential tumor suppressor in human breast carcinomas (5). Tyr323 is a negative regulatory phosphorylation site within the SH2-kinase linker region in Syk. Phosphorylation of Tyr323 provides a direct binding site to the TKB domain of Cbl (6,7). Tyrosine 352 of Syk is involved in the association of PLC-γ1 (8). Tyrosines 525 and 526 are located in the activation loop of the Syk kinase domain, and phosphorylation of Tyr525/526 of human Syk (equivalent to the Tyr519/520 of mouse Syk) is essential for Syk function (9). |
| 存放说明 | -20C |
| 计算分子量 | 72 |
参考图片Western blot analysis of extracts from Ramos cells, untreated or treated with anti-human IgM (12ug/ml, 2 minutes) and Jurkat cells treated with hydrogen peroxide (2mM, 2 minutes) using Phospho-Syk (Tyr525/526) Antibody. |
