Phospho-SHIP1 (Tyr1020) Antibody
货号：
3941S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3941S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-SHIP1 (Tyr1021) Antibody detects endogenous levels of SHIP1 only when phosphorylated at tyrosine 1020 of mouse SHIP1 (or Tyr1021 of human SHIP1). |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate (1). SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus (1,2). Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif (2), followed by tyrosine phosphorylation on the NPXY motif (2). The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1 (3-5). Its effect on calcium flux, cell survival, growth, cell cycle arrest and apoptosis is mediated through the PI3K and Akt pathways (3-5). Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function (6). |
| 存放说明 | -20C |
| 计算分子量 | 145 |
参考图片Western blot analysis of extracts from Ramos cells (human), untreated or IgM-treated (12 µg/ml for 2 minutes) and mouse spleenocytes, untreated or IgG-treated (30 µg/ml), using Phospho-SHIP1 (Tyr1020) Antibody.Western免疫印迹。用Phospho-SHIP1 (Tyr1020) Antibody研究未经处理的和经IgM(12 µg/ml ,2 min)处理的人源Ramos细胞的细胞提取液和未经处理的和经过IgG(30 µg/ml)处理的鼠spleenocytes。 |
