Phospho-SEK1/MKK4 (Ser257/Thr261) Antibody
货号：
9156S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9156S |
| 反应种属 | Human/Mouse/Rat/D.melanogaster |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5). |
| 存放说明 | -20C |
| 计算分子量 | 44 |
参考图片Western blot analysis of extracts from HeLa and C6 cells, untreated or UV-treated, using Phospho-SEK1/MKK4 (Ser257/Thr261) Antibody (upper) or SEK1/MKK4 Antibody #9152 (lower).Western blot 方法检测细胞提取物：未经处理的和紫外照射的HeLa、C6细胞，使用的抗体是Phospho-SEK1/MKK4 (Ser257/Thr261) Antibody (上图)和SEK1/MKK4 Antibody #9152 (下图)。 |
