Phospho-Rad50 (Ser635) Antibody
货号：
14223S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 14223S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage (1-4). Rad50 forms a complex with Mre11 and Nbs1 that becomes activated in response to DNA damage (3). In normal human cells, the MRN complex acts to tether linear DNA molecules, providing a flexible link between DNA ends (1). Genomic instability and cancer have been shown to develop in cells with genetic mutations affecting the proteins in the MRN complex (2). ATM-dependent phosphorylation of Rad50 at Ser635 in response to DNA damage is important in regulating downstream signaling, DNA repair and checkpoint control (5). |
| 存放说明 | -20C |
| 计算分子量 | 153 |
参考图片Western blotting analysis of extracts from 293 cells, untreated (-) or UV-treated (100 mJ, 2 hr; +) or HCT 116 cells, untreated (-) or neocarzinostatin-treated (NCS, 10μM, 1 hr; +) using Phospho-Rad50 (Ser635) Antibody (upper) or Rad50 Antibody #3427 (lower). |
