Phospho-PZR (Tyr263) Antibody
货号：
5543S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 5543S |
| 反应种属 | Human/Mouse/Rat/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Phospho-PZR (Tyr263) Antibody recognizes endogenous levels of PZR protein only when phosphorylated at Tyr263. This antibody does not cross-react with other tyrosine kinase proteins. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3). PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5). There are three alternatively spliced isoforms, designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs (6,7). PZR is the main receptor of ConA and has an important role in cell signaling via c-Src (4). PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3). Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan syndrome (8). |
| 存放说明 | -20C |
| 计算分子量 | 30-50 |
参考图片Western blot analysis of extracts from BAEC cells, untreated or H2O2-treated (0.3 mM for 30 min), using Phospho-PZR (Tyr263) Antibody (upper) and total PZR Antibody # 4157 (lower).未处理货经过H2O2处理（0.3 mM 30分钟）的BAEC细胞提取物进行western blot分析，使用Phospho-PZR (Tyr263)抗体（上）和总PZR抗体#4157（下）进行试验。 |
