Phospho-PTPα (Tyr789) Antibody
货号：
4481S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4481S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | PTPα (PTPRA) is a transmembrane receptor tyrosine phosphatase implicated in the regulation of Src family kinases during the G2 to mitosis entry point. Two identified splice variants differ in the size of the extracellular region; the shorter form appears to be ubiquitously expressed while the larger protein is more limited in distribution (1). The cytoplasmic region of PTPα contains two putative catalytic domains. One phosphatase domain (D1) exhibits catalytic activity while the other (D2) may regulate phosphatase activity by allowing receptor dimer formation (2,3). PTPα is a physiological regulator of Src and Src family kinases (4). Constitutive phosphorylation of the carboxy-terminal Tyr789 of PTPα is essential for dephosphorylation of Src at Tyr527. Phosphorylation of PTPα at this residue also allows binding of the Grb2 inhibitor, restricting PTPα activation of Src (5,6). PKC-mediated phosphorylation of the PTP at Ser180 and Ser204 also increases PTPα phosphatase activity (7). |
| 存放说明 | -20C |
| 计算分子量 | 145 |
参考图片Western blot analysis of C2C12 and COS cell lysates, untreated or alkaline phosphatase (CIP)-treated, using Phospho-PTPα (Tyr789) Antibody (upper) or PTPα Antibody (Gift from Dr. D. Shalloway, Dept. of Molecular Biology and Genetics, Cornell University, Ithaca, NY.) (lower).Western blot方法检测细胞提取物：未经处理和碱性磷酸酶（CIP）处理的C2C12、COS细胞。使用的抗体是Phospho-PTPα (Tyr789) Antibody (上图)和PTPα Antibody (由Dr. D. Shalloway馈赠, Dept. of Molecular Biology and Genetics, Cornell University, Ithaca, NY.)。 |
