Phospho-PSD95 (Tyr236/Tyr240) Antibody
货号：
3919S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3919S |
| 反应种属 | Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-PSD95 (Tyr236/Tyr240) Antibody detects endogenous levels of PSD95 protein only when phosphorylated at Tyr236 or Tyr240. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Postsynaptic Density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These family members consist of an amino-terminal variable segment followed by three PDZ domains, a SH3 domain and an inactive guanylate kinase (GK) domain. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (1-2). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (3). It is implicated in experience dependent plasticity and plays an indispensable role in learning (4). Mutations in PSD95 are associated with autism (5).Phospho-PSD95 (Tyr236/Tyr240) Antibody is directed against previously unpublished PSD95 tyrosine phosphorylation sites at Tyr236 and Tyr240 that were identified at Cell Signaling Technology (CST) using PhosphoScan®, CSTs MS/MS platform for phosphorylation site discovery. Phosphorylation of PSD95 at Tyr236 and Tyr240 was observed in extracts isolated from ischemic rat brain. The sites were independently found in a large-scale identification of tyrosine phosphorylation sites from murine brain (6). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
参考图片Western blot analysis of extracts from rat brain, either sham operated or subjected to ischemia (15 min) alone or followed by reperfusion (4 hours), using Phospho-PSD95 (Tyr236/Tyr240) Antibody (upper) and PSD95 Antibody #2507 (lower). Western blot分析大鼠大脑（假手术、仅15分钟缺血或15分钟缺血后再灌注4小时），使用的抗体是Phospho-PSD95 (Tyr236/Tyr240) Antibody 兔多抗（上图）或 PSD95 Antibody 兔多抗#2507（下图）。 |
