| 货号 | 2930S |
| 反应种属 | Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Phospho-PSD93 (Tyr340) Antibody detects endogenous levels of PSD93 only when phosphorylated at Tyr340. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Postsynaptic Density Protein 93 (PSD93) is a member of the PSD subfamily of the membrane-associated guanylate kinase (PSD-MAGUK) proteins. Structurally, it most closely resembles PSD95, consisting of an N-terminal variable segment followed by three PDZ domains, an SH3 domain and an inactive guanylate kinase (GK) domain (1,2) . PSD93 is expressed in neuronal cells and located at the synapse where it interacts with neuronal receptors and proteins including the NMDA receptor (2-4), K+ channels (5-6), and the AMPA receptor (7) to regulate their membrane localization and neuronal signaling. PSD93 is implicated in postsynaptic related persistent pain induction and is a potential target for treatment of this syndrome (3).The phosphorylation site at Tyr340 of PSD93 was identified at Cell Signaling Technology (CST) using PhosphoScan®, CSTs MS/MS platform for phosphorylation site discovery. Phosphorylation of PSD93 at Tyr340 was observed in extracts isolated from reperfusion of ischemic rat brain. |
| 存放说明 | -20C |
| 计算分子量 | 110 |
Western blot analysis of extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion, or 15 min ischemia only, using Phospho-PSD93 (Tyr340) Antibody (upper) or PSD95 Antibody (lower). Western blot分析大鼠大脑（15分钟缺血后再灌注4小时或仅15分钟缺血），使用的抗体Phospho-PSD93 (Tyr340) Antibody 兔多抗（上图）或 PSD95 Antibody 兔多抗（下图）。 |
