Phospho-PNK1 (Ser114/Thr118) Antibody
货号：
3522S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3522S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | PNK (polynucleotide kinase) is a DNA repair enzyme that participates in single strand break repair and non-homologous end rejoining (NHEJ) for double strand breaks. PNK possesses a 5-DNA kinase activity and a 3-DNA phosphatase activity (1,2). It has three domains, a C-terminal kinase domain, a central phosphatase domain, and an N-terminal forkhead associated (FHA) domain that is responsible for protein-protein interactions. Reduction in expression of PNK by RNAi sensitizes cells to ionizing radiation and topoisomerase I inhibitors (3)PNK (多核苷酸激酶)是一种DNA修复酶，它参与单链断裂修复和双链断裂的非同源末端重组。PNK拥有5-DNA激酶活性和3-DNA磷酸酶活性(1,2)。它有三个结构域：一个羧基末端激酶结构域，一个中心的磷酸酶结构域，一个负责蛋白-蛋白相互作用的氨基末端叉头相关(FHA)结构域。RNAi引起的PNK1表达降低使细胞对离子辐射和拓扑异构酶抑制剂敏感(3)。 |
| 存放说明 | -20C |
| 计算分子量 | 59 |
参考图片Western blot analysis of extracts of 293 and HeLa cells, either untreated or treated with UV radiation, using Phospho-PNK1 (Ser114/Thr118) Antibody (upper). β-actin Antibody #4967 (lower) was used to control for loading.Western blot检测293和Hela细胞提取物，分为未处理组或紫外辐射组，使用的抗体为 Phospho-PNK1 (Ser114/Thr118) Antibody (上图)。β-actin Antibody #4967作为内对照。 |
