Phospho-PI3 Kinase Class III (Ser249) Antibody
货号：
13857S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 13857S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) (1). PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation (2,3). PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting (4). Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway (5). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with constructs expressing Myc/DDK-tagged human PI3 kinase class III protein (hPI3 Kinase Class III-Myc/DDK; +) or mouse ULK1 protein (mULK1; +), using Phospho-PI3 Kinase Class III (Ser249) Antibody (upper panel), PI3 Kinase Class III (D4E2) Rabbit mAb #3358 (upper middle panel), ULK1 (D8H5) Rabbit mAb #8054 (lower middle panel), and β-Actin (D6A8) Rabbit mAb #8457 (lower panel). |
