Phospho-MKK3 (Ser189)/MKK6 (Ser207) Antibody
货号：
9231S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9231S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site Thr-Gly-Tyr but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5). Activation of MKK3 and MKK6 occurs through phosphorylation of serine and threonine residues at sites Ser189 and Thr193 for MKK3 (2) and Ser207 and Thr211 for MKK6 (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 40 Phospho-MKK3. 41 Phospho-MKK6. |
参考图片Western blot analysis of extracts from NIH/3T3 cells, untreated or anisomycin-treated for the indicated times, using Phospho-MKK3/MKK6 (Ser189/207) Antibody (upper) or MKK3 Antibody #9232 (lower).Western blot 方法检测细胞提取物：未经处理的和用茴香霉素按规定时间处理的、NIH/3T3细胞，使用的抗体是Phospho-MKK3/MKK6 (Ser189/207) Antibody (上图)和MKK3 Antibody #9232 (下图)。 |
