Phospho-M-CSF Receptor (Tyr809) Antibody
货号：
3154S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3154S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-M-CSF Receptor (Tyr809) Antibody detects endogenous levels of M-CSF receptors only when phosphorylated at tyrosine 809. The antibody may cross-react slightly with activated KDR and PDGF receptors. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLC-γ 2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8). |
| 存放说明 | -20C |
| 计算分子量 | 175 |
参考图片Western blot analysis of extracts from Bac1.2F5 and FDCP1/fms cells overexpressing mouse M-CSF receptors, untreated or M-CSF-stimulated (40 ng/ml for 1 minute), using Phospho-M-CSF Receptor (Tyr809) Antibody.用抗磷酸化M-CSF 受体(Tyr809)的抗体对经过或未经M-CSF (40 ng/m，1分钟)刺激后高表达M-CSF受体的Bac1.2F5和FDCP1/fms细胞的提取物进行免疫印迹检测。 |
