Phospho-Mcl-1 (Ser64) Antibody
货号：
13297S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 13297S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Mcl-1 (Ser64) Antibody recognizes endogenous levels of Mcl-1 protein only when phosphorylated at Ser64. Non-specific bands of unknown origin are detected in some cell lines at 70 and 140 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Phosphorylation of Mcl-1 at Ser64 can target it for ubiqutination and destruction by the tumor suppressor protein FBW7 (14,15).Mcl-1在Ser64位点的磷酸化，可以使其成为肿瘤抑制蛋白FBW7诱导的泛素化降解的靶点(14,15)。 |
| 存放说明 | -20C |
| 计算分子量 | 40 |
参考图片Western blot analysis of extracts from HCT 116 and KARPAS-299 cells, untreated (-) or treated with MG-132 #2194 (10 μM, overnight; +) using Phospho-Mcl-1 (Ser64) Antibody (left). Phospho-specificity is demonstrated by antibody competition with peptides specific for phospho-Mcl-1 (Ser64) (middle) or non-phospho-Mcl-1 (Ser64) (right). Western blot分析未处理(-)或经过MG-132 #2194 (10 μM，过夜；+）处理的HCT 116 和KARPAS-299细胞的细胞提取物，使用Phospho-Mcl-1 (Ser64) 抗体(左)。用针对phospho-Mcl-1 (Ser64)的特异性肽段(中)或non-phospho-Mcl-1 (Ser64)(右)的特异性肽段进行抗体竞争性实验验证了磷酸化特异性。 |
