Phospho-LKB1 (Ser334) Antibody
货号：
3055S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3055S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-LKB1 (Ser334) Antibody detects transfected levels of LKB1 only when phosphorylated at serine 334. The antibody does not cross-react with LKB1 phosphorylated at other sites. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites,
including human LKB1 at Ser31/325/428 and Thr189/336/363 (5).
Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7). |
| 存放说明 | -20C |
| 计算分子量 | 54 |
参考图片Western blot analysis of extracts from COS cells, untransfected or transfected with Wild-type LKB1, LKB1 (T189A), LKB1 (S334A) or LKB1 (S428A), using Phospho-LKB1 (Ser334) Antibody . 对COS细胞，未转染或转染野生型LKB1、LKB1(T189A)、LKB1(S334A)或LKB1(S428A)，使用Phospho-LKB1 (Ser334)抗体进行Western blot分析。 |
