Phospho-IκBε (Ser18/22) Antibody
货号：
4924S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4924S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-IκBε (Ser18/22) Antibody detects endogenous levels of IκBε only when phosphorylated at serines 18 and 22. No cross-reactivity was detected with other family members at physiological conditions. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8). |
| 存放说明 | -20C |
| 计算分子量 | 45 |
参考图片Western blot analysis of extracts from 293 cells treated with TNF-α (20 ng/ml) for the indicated times, using Phospho-IκBε (Ser18/22) Antibody.Western免疫印迹。用Phospho-IκBε (Ser18/22) Antibody研究经TNF-α (20 ng/ml)处理一定时间的293 细胞的细胞提取液。 |
