Phospho-IκBβ (Thr19/Ser23) Antibody (Human Specific)
货号：
4921S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4921S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-IκBβ (Thr19/Ser23) Antibody detects endogenous levels of human IκBβ only when phosphorylated at threonine 19 and serine 23. This antibody also recognizes phosphorylation at Ser19/Ser23 also reported as the sequence for IκBβ. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8). |
| 存放说明 | -20C |
| 计算分子量 | 48 to 50 |
参考图片Western blot analysis of extracts from HT-29 cells treated with TNF-α (#2169, 20 ng/ml) and calyculin A (#9902, 100 nM) for 10 minutes as indicated, using Phospho-IκBβ (Thr19/Ser23) Antibody (upper) or IκBβ Antibody #9248 (lower).Western免疫印迹。用Phospho-IκBβ (Thr19/Ser23) Antibody (上图) 或 IκBβ Antibody #9248 (下图)研究经TNF-α (#2169, 20 ng/ml) 和 calyculin A (#9902, 100 nM,10 min) 处理的HT-29 细胞的细胞提取液。 |
