Phospho-IP3 Receptor (Ser1756) Antibody
货号：
3760S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3760S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-IP3 Receptor (Ser1756) Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Ser1756. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3R1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation (1). Four individual receptor subunits, resulting in homo- or hetero-oligomerization of the receptor isoform, form a functional channel (2). Phosphorylation of IP3R1 at Ser1756 by cyclic-AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release (3,4). IP3R1-mediated Ca2+ release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells (5). |
| 存放说明 | -20C |
| 计算分子量 | 320 |
参考图片Western blot analysis of extracts from mouse brain using Phospho-IP3 Receptor (Ser1756) Antibody. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide, with IP3 Receptor (Ser1756) phosphopeptide or with IP3 Receptor (Ser1756) non-phosphopeptide prior to incubating the membrane. 对小鼠脑抽提液使用Phospho-IP3 Receptor (Ser1756)抗体进行Western blot分析。磷酸化特异性由无肽段抗体预孵，及孵膜前伴IP3 Receptor (Ser1756)磷酸化或非磷酸化验证。 |
