Phospho-HSP27 (Ser15) Antibody
货号：
2404S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 2404S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-HSP27 (Ser15) Antibody detects endogenous levels of HSP27 only when phosphorylated at serine 15. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 27 |
参考图片Western blot analysis of extracts from HeLa and COS cells, untreated, anisomycin-treated or UV-treated, using Phospho-HSP27 (Ser15) Antibody (upper) or HSP27 (G31) Monoclonal Antibody #2402 (lower). 对HeLa和COS细胞抽提液，未处理或anisomycin处理或UV处理，使用Phospho-HSP27 (Ser15) Antibody（上图）或HSP27 (G31) Monoclonal Antibody #2402（下图）进行Western blot分析。 |
