Phospho-HER4/ErbB4 (Tyr984) Antibody
货号：
3790S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3790S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-HER4/ErbB4 (Tyr984) Antibody detects endogenous levels of HER4/ErbB4 protein only when phosphorylated on Tyr984. This antibody may cross-react with other tyrosine-phosphorylated proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The HER/ErbB receptor tyrosine kinase family has been implicated in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3). |
| 存放说明 | -20C |
| 计算分子量 | 180 |
参考图片Western blot analysis of extracts from T-47D cells, untreated or heregulin-stimulated, using Phospho-HER4/ErbB4 (Tyr984) Antibody (upper) and HER4/ErbB4 (111B2) Rabbit mAb#4795 (lower).Western blot法检测细胞的提取物：未处理或用neuregulin (NRG)处理的T47D细胞。使用抗体为：Phospho-HER4/ErbB4 (Tyr984) Antibody (上) 和HER4/ErbB4 (111B2) Rabbit mAb#4795 (下)。 |
