Phospho-GSK-3α/β (Ser21/9) Antibody
货号：
9331S 基本售价：
3980.0 元 规格：
100ul
产品信息
概述| 货号 | 9331S |
| 反应种属 | Human/Mouse/Rat/Monkey/Zebrafish |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | Phospho-GSK-3alpha/beta (Ser21/9) Antibody detects endogenous levels of GSK-3 only when phosphorylated at serine 21 of GSK-3alpha or serine 9 of GSK-3beta. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). |
| 存放说明 | -20C |
| 计算分子量 | 46 GSK-3beta. 51 GSK-3alpha. |
参考图片Western blot analysis of extracts from 293 cells, untreated or insulin treated for the indicated times, using Phospho-GSK-3alpha/beta (Ser21/9) Antibody (upper) or GSK-3beta Antibody #9332 (lower). Western blot 分析293细胞胰岛素非处理组和处理组，所用抗体为PhosphoGSK-3α/β (Ser21/9) Antibody (上) 或 GSK-3β Antibody #9332 (下). |
