Phospho-Gab2 (Tyr452) Antibody
货号：
3881S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3881S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Gab2 (Tyr452) Antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 452. This antibody cross-reacts with phosphorylated Gab1 and Gab3. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | he Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9). Gab2 is also phosphorylated by tyrosine kinases (10,11). Tyr452 is a potential binding site of p85, the regulatory subunit of PI3 kinase. Tyr614 is essential for SHP2 association (11). Furthermore, Akt phosphorylates Gab2 at Ser159 and inhibits Gab2 tyrosine phosphorylation, suggesting that Akt is engaged in negative feedback regulation of Gab2 signaling (12). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
参考图片Western blot analysis of extracts from BaF3 cells, untreated or treated with Flt3 ligand, using Phospho-Gab2 (Tyr452) Antibody.Western blot 检测分析BaF3细胞提取物，未处理的和Flt3 ligand刺激的；使用的抗体是 Phospho-Gab2 (Tyr452) 。 |
