Phospho-Gab2 (Ser159) Antibody
货号：
3884S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3884S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Gab2 (Ser159) Antibody detects endogenous levels of Gab2 only when phosphorylated at serine 159. This antibody does not cross-react with Gab1 or Gab3. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold (1-4). Multiple tyrosine phosphorylation sites of Gab1 protein have been identified (5). Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase (6,7). Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ (8). Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2 (6,9).Akt phosphorylates Gab2 at Ser159. This phosphorylation inhibits Gab2 tyrosine phosphorylation and downstream signal amplification (10). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
参考图片Western blot analysis of extracts from H-4-II-E cells, untreated, HGF-treated, insulin-treated or treated with lambda phosphatase after lysis, using Phospho-GAB2 (Ser159) Antibody. Western blot 检测分析H-4-II-E细胞提取物，分为未处理组， HGF处理组，胰岛素处理组或者γ-phosphatase处理组，使用的抗体是 Phospho-GAB2 (Ser159) 。 |
