Phospho-FRS2-α (Tyr196) Antibody
货号：
3864S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3864S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine-phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR). Activation of the FGFR leads to tyrosine phosphorylation of FRS2 (1). Two FRS2 family members have been identified, FRS2-alpha (SNT1) and FRS2-beta (SNT2) (2), which are phosphorylated by these RTKs. Once they are phosphorylated, they recruit SH2 domain-containing proteins including Grb2 and SHP-2 (3,4), mediating downstream signaling. Tyr436 is required for efficient SHP-2 recruitment (5), whereas Tyr196 functions as a docking site for Grb2-Sos complexes (6). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
参考图片Western blot analysis of extracts from NIH/3T3 cells, untreated or stimulated with bFGF and/or treated with calf intestinal phosphatase (CIP) as indicated, using Phospho-FRS2-alpha (Tyr196) Antibody.Western blot方法检测细胞提取物：未经处理的和bFG刺激理的，和/或牛小肠磷酸酶处理的NIH/3T3细胞，使用的抗体是Phospho-FRS2-alpha (Tyr196) Antibody。 |
