Phospho-FLT3 (Tyr591) Antibody
货号：
3461S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3461S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-FLT3 (Tyr591) Antibody detects endogenous FLT3 only when phosphorylated at tyrosine 591. The antibody does not cross-react with other FLT family members. It may cross-react with some tyrosine phosphorylated proteins.
(US Patent No. 7,183,385 and foreign equivalents assigned to Cell Signaling Technology, Inc.) |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1,2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia (7). |
| 存放说明 | -20C |
| 计算分子量 | 130 nonglycosylated form;160 glycosylated mature form |
参考图片Western blot analysis of extracts from BaF3/FLT3 cells, untreated or stimulated with FLT3 Ligand (FL) (3 µg/ml for 5 minutes), using Phospho-FLT3 (Tyr591) Antibody (upper) or FLT3 (8F2) Rabbit mAb #3462 antibody (lower).Western blot检测未处理的或经过FLT3 Ligand (FL) (3 µg/ml， 5 minutes)刺激的BaF3/FLT3细胞的提取物，使用的抗体为：Phospho-FLT3 (Tyr591) Antibody (上) 或 FLT3 (8F2) Rabbit mAb #3462 antibody (下)。 |
