Phospho-FAK (Tyr397) Antibody
货号：
3283S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3283S |
| 反应种属 | Human/Mouse/Rat/Hamster/Pig |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-FAK (Tyr397) Antibody detects endogenous levels of FAK only when phosphorylated at Tyr397. This antibody may cross-react with overexpressed tyrosine phosphorylated EGF receptors. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 125 |
参考图片Western blot analysis of extracts from NIH/3T3 cells, untransfected or transfected with activated Src, using Phospho-FAK (Tyr397) Antibody (upper) or FAK Antibody #3285 (lower).未转染或转染了激活Src的NIH/3T3细胞提取物，使用Phospho-FAK (Tyr397)抗体（上）或FAK抗体#3285（下）进行western blot分析。 |
