Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
货号：
3141S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3141S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody detects endogenous levels of ezrin, radixin and moesin only when phosphorylated at threonine 567, 564 or 558, respectively. This antibody does not cross-react with related phospho-proteins such as merlin or band 4.1. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation (1). ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers (2). Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function (3,4). Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation (5). Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation (6). |
| 存放说明 | -20C |
| 计算分子量 | 75 Moesin. 80 Ezrin, Radixin. |
参考图片Western blot analysis of extracts from A431 cells, untreated or EGF-treated, using Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody (left) or Ezrin/Radixin/Moesin Antibody #3142 (right).使用Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody (左图)或Ezrin/Radixin/Moesin Antibody #3142 (右图)，免疫印迹（Western Blot）分析A431细胞中Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558)和Ezrin/Radixin/Moesin蛋白水平，细胞分为未处理组和EGF处理组。 |
