Phospho-eNOS (Ser113) Antibody
货号：
9575S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9575S |
| 反应种属 | Human/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-eNOS (Ser113) Antibody detects endogenous levels of eNOS only when phosphorylated at serine 113. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Endothelial nitric-oxide synthase (eNOS) is an important enzyme in the cardiovascular system. It catalyzes the production of nitric oxide (NO), a key regulator of blood pressure, vascular remodeling, and angiogenesis (1,2). The activity of eNOS is regulated by phosphorylation at multiple sites. The two most thoroughly studied sites are the activation site Ser1177 and the inhibitory site Thr495 (3). Several protein kinases including Akt/PKB, PKA, and AMPK activate eNOS by phosphorylating Ser1177 in response to various stimuli (4,5). In contrast, bradykinin and H2O2 activate eNOS activity by promoting both Ser1177 phosphorylation and Thr495 dephosphorylation (6,7).eNOS is activated by VEGF, and this activation is associated with dephsophorylation of eNOS at serine 113. Cyclosporin A blocks this dephosphorylation of eNOS upon VEGF stimulation (8). |
| 存放说明 | -20C |
| 计算分子量 | 140 |
