Phospho-DNAJC2/MPP11 (Ser47) Antibody
货号：
12397S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 12397S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-DNAJC2/MPP11 (Ser47) Antibody recognizes endogenous levels of DNAJC2/MPP11 protein only when phosphorylated at Ser47. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | DnaJ/Hsp40 proteins are a conserved family of J-domain-containing chaperone proteins that assist in protein folding and stability through their interactions with Hsp70 chaperone proteins (reviewed in 1). DNAJC2, also known as MPP11 (M-phase phosphoprotein 11 protein), is a component of the ribosome-associated complex (RAC). The RAC is localized to the cytoplasm, where it assists in maintaining appropriate folding of nascent polypeptides by stimulating the ATPase activity of Hsp70 chaperone proteins (2,3). In the nucleus, MPP11 is involved in the activation of transcription through mediation of the switch from polycomb-repressed to active chromatin (4). Previous studies have shown MPP11 is overexpressed in leukemia and head and neck cancer, leading researchers to suggest MPP11 may be a potential therapeutic target (5-7).
Phospho-DNAJC2/MPP11 (Ser47) Antibody is directed at a site that was identified at Cell Signaling Technology (CST) using PhosphoScan®, CSTs LC-MS/MS platform for modification site discovery. Please visit PhosphoSitePlus®, CSTs modification site knowledgebase, at www.phosphosite.org for more information. |
| 存放说明 | -20C |
| 计算分子量 | 80 |
参考图片Western blot analysis of 293T cells, untreated (-) or treated (+) with λ phosphatase and calf intestinal phosphatase (CIP), using Phospho-DNAJC2/MPP11 (Ser47) Antibody (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). Western blot方法检测未经处理（-）或λ磷酸酶和牛小肠磷酸酶 (CIP)处理(+)的293T细胞提取物，使用的抗体为Phospho-DNAJC2/MPP11 (Ser47) Antibody (上图) 和 α-Actinin (D6F6) XP® Rabbit mAb 兔单抗#6487 (下图)。 |
