Phospho-Desmoplakin (Ser165/166) Antibody
货号：
5885S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 5885S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Desmoplakin (Ser165/166) Antibody recognizes endogenous levels of desmoplakin protein only when phosphorylated at Ser165/166. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Desmosomes are a class of intracellular junction that tightly link adjacent cells in mechanically stressed tissues such as the epithelium and myocardium (1). They derive their characteristic strength from the protein Desmoplakin, which acts as a tether by binding the cytoplasmic component of the Desmosome at it’s N-terminus (2) while its C-terminus is anchored to the intermediate-filament cytoskeleton (3). This association mitigates the impact of mechanical forces on the desmosome by distributing them throughout the cytoskeleton and tissue (4). Desmoplakin is essential for normal desmosomal adhesion (5); defects can result in pathologies that include cardiomyopathy (6), keratoderma (7), or the skin blistering disease Epidermolysis bullosa (8). |
| 存放说明 | -20C |
| 计算分子量 | 250 |
参考图片Western blot analysis of extracts from A-431 and Calu-3 cells, untreated or treated with calf intestinal phosphatase (CIP) and λ phosphatase, using Phospho-Desmoplakin (Ser165/166) Antibody.未处理或经过牛小肠碱性磷酸酶（CIP）和λ磷酸酶处理的A-431和Calu-3细胞提取物进行western blot分析，使用Phospho-Desmoplakin (Ser165/166)抗体进行实验。 |
