| 货号 | 5294S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Phospho-CTDSPL2 (Ser104) Antibody detects endogenous levels of CTDSPL2 only when phosphorylated at Ser104. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | CTD small phosphatase-like protein 2 (CTDSPL2, HSPC129) is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase (1) that belongs to a small subfamily of CTD phosphatases (2). The CTD of RNA polymerase II contains multiple Y-S-P-T-S-P-S repeats that are phosphorylated during the transcription cycle (3,4). In general, CTD phosphatases regulate the reversible CTD phosphorylation state of RNA-polymerase II at several stages of RNA synthesis and during post-transcriptional modification (4-6). CTDSPL2 has several structural and functional similarities to other CTD phosphatases, including FCP1, SCP1, DULLARD, and UBLCP1 (1,2). |
| 存放说明 | -20C |
| 计算分子量 | 61 |
Western blot analysis of extracts from NCI-H1703 cells, untreated or EGF-treated, and HeLa cells, untreated or λ-phosphatase-treated, using Phospho-CTDSPL2 (Ser104) Antibody (upper) and a total CTDSPL2 antibody (lower). 使用Phospho-CTDSPL2 (Ser104) Antibody (上图)和总的CTDSPL2 antibody (下图)，免疫印迹(Western blot)分析未处理或EGF处理的NCI-H1703和HeLa细胞中Phospho-CTDSPL2 (Ser104)和CTDSPL2的蛋白水平。 |
