Phospho-CRMP-2 (Thr514) Antibody
货号：
9397S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9397S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-CRMP-2 (Thr514) Antibody detects endogenous levels of CRMP-2 only when phosphorylated at Thr514. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5). |
| 存放说明 | -20C |
| 计算分子量 | 55-65 |
参考图片Western blot analysis of extracts from PC12 cells, untreated or λ phosphatase treated, using Phospho-CRMP-2 (Thr514) Antibody (upper) or CRMP-2 Antibody #9393 (lower). Western blot分析PC12细胞（未处理，或λ磷酸酶处理）提取物，使用的抗体是Phospho-CRMP-2 (Thr514) Antibody 兔多抗（上图）或CRMP-2 Antibody 兔多抗 #9393（下图）。 |
