Phospho-Connexin 43 (Ser368) Antibody
货号：
3511S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3511S |
| 反应种属 | Human/Mouse/Rat/Hamster/MonkeyDog |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Connexin 43 (Ser368) Antibody detects endogenous levels of connexin 43 only when phosphorylated at serine 368. The antibody does not cross-react with other phosphorylated connexin family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions (1,2). Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication (3). Src can interact with and phosphorylate Cx43 to alter gap junction communication (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 42, 44, 46 |
参考图片Western blot analysis of extracts from COS and C6 cells, untreated or PMA-treated, using Phospho-Connexin 43 (Ser368) Antibody.对未处理或经过PMA处理的COS和C6细胞提取物，使用Phospho-Connexin 43 (Ser368)抗体进行westernblot分析。 |
