Phospho-Cofilin (Ser3) Antibody
货号：
3311S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3311S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Cofilin (Ser3) Antibody detects endogenous levels of cofilin only when phosphorylated at serine 3. The antibody may cross-react with phosphorylated cofilin 2, the muscle isoform. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Cofilin and ADF (actin-depolymerization factor) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration (1). In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin (3-5). Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm (6). |
| 存放说明 | -20C |
| 计算分子量 | 19 |
参考图片Western blot analysis of extracts from HeLa cells, untreated or H2O2-treated, using Phospho-Cofilin (Ser3) Antibody (A and B) or Cofilin Antibody #3312 (C and D). Membranes (B and D) were treated with alkaline phosphatase (CIP) to demonstrate the phospho-specificity the antibody.使用Phospho-Cofilin (Ser3) Antibody (A和B)或Cofilin Antibody #3312 (C和D)，免疫印迹（Western Blot）分析HeLa细胞系，细胞分为untreated组或H2O2-treated组。alkaline phosphatase (CIP)处理膜(B和D)从而证明磷酸化特异性抗体。 |
Western blot analysis of extracts from asynchronous or mitotic C6, CHO and COS cells, using Phospho-Cofilin (Ser3) Antibody (upper) or Cofilin Antibody #3312 (lower).使用Phospho-Cofilin (Ser3) Antibody (上图)或Cofilin Antibody #3312 (下图)，免疫印迹（Western Blot）分析不同时期或有丝分裂期的C6、CHO和COS细胞系中Phospho-Cofilin (Ser3)和Cofilin蛋白水平。 |
