Phospho-c-Jun (Thr91) Antibody
货号：
2303S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 2303S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12). |
| 存放说明 | -20C |
| 计算分子量 | 48 |
参考图片Western blot analysis of extracts from untreated or UV-treated COS and NIH/3T3 cells, using Phospho-c-Jun (Thr91) Antibody (upper) or c-Jun (60A8) Rabbit mAb #9165 (lower).Western blot方法检测细胞提取物：紫外照射和未经处理的NIH/3T3、COS细胞。使用的抗体是Phospho-c-Jun (Thr91) Antibody (上图)和c-Jun (60A8) Rabbit mAb #9165 (下图)。 |
