Phospho-c-Jun (Ser73) Antibody【科瑞奥博】

产品中心

当前位置：首页>产品中心

Phospho-c-Jun (Ser73) Antibody

货号： 9164S 基本售价： 3980.0 元规格： 100ul

产品信息

概述
货号	9164S
反应种属	Human/Mouse/Rat/Monkey
来源宿主	Rabbit
应用	W/IF-IC
使用方法	WB(1:1000) IF-IC (1:100)

性能
供应商	CST
背景	c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12).
存放说明	-20C
计算分子量	48

参考图片

Western blot analysis of extracts from UV-treated NIH/3T3 cells using Phospho-c-Jun (Ser73) Antibody.Western blot方法检测细胞提取物：紫外照射的NIH/3T3细胞。使用的抗体是Phospho-c-Jun (Ser73) Antibody。

Western blot analysis of extracts from NIH/3T3 cells treated with anisomycin (25 ug/ml) for the indicated times, using Phospho-c-Jun (Ser73) Antibody #9164. The lower molecular weight band is phospho-JunD (Ser100).Western blot方法检测细胞提取物：按规定时间用茴香霉素(25 ug/ml)处理NIH/3T3细胞。使用的抗体是Phospho-c-Jun (Ser73) Antibody #916。表示分子大小的最下面一行条带是phospho-JunD (Ser100)。

Confocal immunofluorescent images of C6 cells, untreated (left) or anisomycin treated (right), labeled with Phospho-c-Jun (Ser73) Antibody (green) and beta-Tubulin Antibody #2146 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).激光共聚焦荧光法检测：未经处理的（左侧）和茴香霉素处理的（右侧）C6细胞。标记的抗体是PPhospho-c-Jun (Ser73) Antibody (绿色)和beta-Tubulin Antibody #2146 (红色)。蓝色伪彩为DNA荧光染料（产品信息为 DRAQ5®#4084 ）。